Description
This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers’ horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury – Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline. Part I Introduction 1. The History and Evolution of Experimental Traumatic Brain Injury ModelsJohn PovlishockPart II. General Consideration in Using Animal Laboratory in CNS Injury Research2. Clinical Traumatic Brain Injury in the Preclinical SettingJustin Berkner, Rebekah Mannix, and Jianhua Qiu3. Rodent Models of Traumatic Brain Injury: Methods and ChallengesNiklas Marklund4. Traumatic Brain Injury Models in AnimalsElham Rostami5. Systematic Review of Traumatic Brain Injury Animal ModelsHelen W. Phipps6. Methods of Drug Delivery in NeurotraumaYing Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, and Deborah Shear7. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental TestingPamela J. VandeVord, Alessandra Dal Cengio Leonardi, and David Ritzel8. Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Set-UpsZachary S. Bailey, William Brad Hubbard, and Pamela J. VandeVord9. Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics for Traumatic Brain InjuryZaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, and Firas Kobeissy10. Role of Systems Biology in Brain Injury Biomarker Discovery: A Neuroproteomic ApplicationZaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, Hiba Ghandour, Stefania Mondello, and Firas KobeissyPart III Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury – Models11. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and ProtocolNicole Osier and C. Edward Dixon12. Weight Drop Models in Traumatic Brain InjuryBrian T. Kalish and Michael J. Whalen13. Midline (Central) Fluid Percussion Model of Traumatic Brain InjuryRachel K. Rowe, Daniel R. Griffiths, and Jonathan Lifshitz14. Lateral (Parasagittal) Fluid Percussion Model of Brain InjuryKen C. Van and Bruce G. Lyeth15. Impact Acceleration Model of Diffuse Traumatic Brain InjurySarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, and M. Cristina Morganti-Kossmann16. Experimental Models for Neurotrauma ResearchJohan Davidsson and Mrten Risling
