Description
This third volume in the “Progress in Hypertension” series is dedicated to the memory of Professor Kozo Okamoto the creator of spontaneously hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHRSP) and malignant stroke-prone spontaneously hypertensive rats (M-SHRSP). The papers in this volume deal with pathophysiology and pharmacology of SHR. The contributions describe new trends in SHR research from haemodynamic characteristics to immunological views. The emphasis is placed on the development of transgenic rats and the use of tissue culture studies to elaborate SHR characteristics. The possible use of SHRSP as a model of cerebrovascular dementia can also serve as a novel concept to facilitate the study of vascular dementia. The role of excitatory amino SHR are also covered in this book.
