Description
Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof. 1. Mona Alidadi, Amirhossein Sahebkar, Saeid Eslami, Farveh Vakilian, Lida Jarahi, Maryam Alinezhad-Namaghi, Seyed Mostafa Arabi, Saba Vakili, Fariba Tohidinezhad, Yasaman Nikooiyan, Abdolreza Norouzy Title: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. 2. Abolfazl Amini, Parand Khadivar, Ali Ahmadnia, Morteza Alipour, Muhammed Majeed, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar Title: Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer. 3. Seyed Reza Mirhafez, Mohsen Azimi-Nezhad, Maryam Dehabeh, Mitra Hariri, Ronika Danesh Naderan, Ali Movahedi, Mohammed Abdalla, Thozhukat Sathyapalan, Amirhossein Sahebkar Title: The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial. 4. Mahdi Hatamipour, Tannaz Jamialahmadi, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Luis E. Simental-Menda, Mohammad Reza Sarborji, Maciej Banach, Amirhossein Sahebkar Title: Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis. 5. Amir Abbas Momtazi-Borojeni, Narges Amel Zabihi, Ramin Khameneh Bagheri, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar Title: Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits. 6. Melika Naji, Setareh Soroudi, Maryam Akaberi1, Amirhossein Sahebkar, Seyed Ahmad Emami Title: Updated review on the role of curcumin in gastrointestinal cancers. 7. Neda Shakour, Ricardo Cabezas, Janneth Gonzlez, George E. Barreto, Tannaz Jamialahmadi, Farzin Hadizadeh, Amirhossein Sahebkar Title: Curcumin can bind and interact with CRP: an in silico study. 8. Hossein Zarrinfar, Mahsa Behnam, Mahdi Hatamipour, Amirhossein Sahebkar Title: Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates. 9. Seyed Mojtaba Sohrevardi, Behrooz Heydari, Mahmoud Reza Azarpazhooh, Mohammad Teymourzadeh, Luis E. Simental-Menda, Stephen L. Atkin, Amirhossein Sahebkar, Mojgan Karimi-Zarchi Title: Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial. 10. Yunes Panahi, Ashraf Karbasi, Ghasem Valizadegan, Nayyereh Ostadzadeh, Sara Saffar Soflaei, Tannaz Jamialahmadi, Muhammed Majeed, Amirhosein Sahebkar Title: Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial. 11. Zinat Heidari, Marzieh Mohammadi, Amirhossein Sahebkar Title: Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19. 12. Milad Ashrafizadeh, Shima Tavakol, Reza Mohammadinejad, Zahra Ahmadi, Habib Yaribeygi, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar Title: Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress. 13. Atena Mahdavi, Mohammad Bagherniya, Mohammad Sadegh Mirenayat, Stephen L. Atkin, Amirhossein Sahebkar Title: Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review. 14. Eduardo Luis Konrath, Marcelo Dutra Arbo, Bruno Dutra Arbo, Mariana Appel Hort, Elaine Elisabetsky, Mirna Bainy Leal Title: Plants with anti-addictive potential. 15. Diana Lelli, Livio Cortese, Claudio Pedone Title: Use of Plant-Derived Natural Products in Sleep Disturbances. 16. Fateme Gharibpour, Farinaz Shirban, Mohammad Bagherniya, Mohsen Nosouhian, Thozhukat Sathyapalan, Amirhossein Sahebkar Title: The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review. 17. Luca Liberale, Fabrizio Montecucco, Federico Carbone Title: Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health. 18. Luis E. Simental-Menda, Claudia I. Gamboa-Gmez, Fernando Guerrero-Romero, Mario Simental-Menda, Adriana Snchez-Garca, Mariana Rodrguez-Ramrez Title: Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease. 19. Habib Yaribeygi, Stephen L. Atkin, George E. Barreto, Amirhossein Sahebkar Title: Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats. 20. Bahareh Sadat Yousefsani, George E. Barreto, Amirhossein Sahebkar Title: Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine. 21. Zahra Boghrati, Sara Sabouri-Rad, Seyed Ahmad Emami, Mohsen Tahaghoghi Saber, Amirhossein Sahebkar, Zahra Tayarani-Najaran Title: The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review. 22. Leila Mohtashami, Mohammad Sadegh Amiri, Zahra Ayati, Mahin Ramezani, Tannaz Jamialahmadi, Seyed Ahmad Emami, Amirhossein Sahebkar Title: Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review. 23. Zahra Ayati, Mahin Ramezani, Mohammad Sadegh Amiri, Amirhossein Sahebkar, Seyed Ahmad Emami Title: Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM). 24. Sofia Salari, Mohammad Sadegh Amiri, Mahin Ramezani, Ali Tafazoli Moghadam, Sepideh Elyasi, Amirhossein Sahebkar, Seyed Ahmad Emami Title: Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review. 25. Farshad Abedi Torbati, Mahin Ramezani, Reza Dehghan1, Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Neda Shakour, Sepideh Elyasi, Amirhossein Sahebkar, Seyed Ahmad Emami Title: Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review. 26. Zahra Boghrati, Elaheh Zibaee, Zahra Ayati, Mohammad Sadegh Amiri, Mahin Ramezani, Tannaz Jamialahmadi, Seyed Ahmad Emami, Amirhossein Sahebkar Title: Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review. 27. Zahra Sobhani, Maryam Akaberi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami, Amirhossein Sahebkar Title: Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology. 28. Yunes Panahi, Mojtaba Mojtahedzadeh, Atabak Najafi, Mohammadreza Gheini, Mohammad Abdollahi, Mohammad Sharifzadeh, Arezoo Ahmadi, Shiva Ganjali, Seyyed Mahdi Rajaee, George E. Barreto, Amirhossein Sahebkar Title: Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial. 29. Ricardo Cabezas, Amirhossein Sahebkar, Valentina Echeverria, Janneth Gonzalez, Ghulam Md Ashraf, George E. Barreto Title: In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.
