Description
This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. “With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction.” – Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine PART 1: SKIN AND SOFT TISSUE REGENERATION 1. Induction of the Fetal Scarless Phenotype in Adult Wounds: Impossible? 2. Scar Treatment and Prevention: Know Thine Enemy 3. Challenges and Opportunities in Drug Delivery and Wound Healing 4. Harvesting, Processing and Injection of Lipoaspirate for Soft Tissue Reconstruction – Details Make the Difference 5. Adipose Tissue Complex (ATC): Cellular & Biocellular Uses of Stem/Stromal Cells & Matrix in Cosmetic Plastic, Reconstructive Surgery & Regenerative Medicine 6. Preparation, Characterization, and Clinical Implications of Human Decellularized Adipose Tissue Extracellular Matrix 7. Mesenchymal Cells that Support Human Skin Regeneration 8. Stem Cells and Burn 9. Skin Tissue Engineering Advances in Severe Burns: Review and Therapeutic Applications 10. Skin Substitutes for Burn Wounds 11. Wnt Signaling During Cutaneous Wound Healing 12. Drug Delivery Advances for the Regeneration of Aged Skin PART 2: BONE REGENERATION 13. Innovative Scaffold Solution for Bone Regeneration Made of Beta-Tricalcium Phosphate Granules, Autologous Fibrin Fold and Peripheral Blood Stem Cells 14. Ordinary and Activated Bone Substitutes 15. Absorbable Bone Substitute Materials Based on Calcium Sulfate as Triggers for Osteoinduction and Osteoconduction 16. Perivascular Progenitor Cells for Bone Regeneration 17. Bone Repair and Regeneration is Regulated by the Wnt Signaling Pathway PART 3: CARTILAGE REGENERATION 18. Cartilage Tissue Engineering: Role of Mesenchymal Stem Cells, Growth Factors and Scaffolds 19. Sox9 Potentiates BMP2-induced Chondrogenic Differentiation and Inhibits BMP2-induced Osteogenic Differentiation 20. Stem Cells and Ear Regeneration PART 4: MUSCLE AND TENDON REGENERATION 21. Muscle Fiber Regeneration in Long Term Denervated Muscles. Basics and Clinical Perspectives 22. Rejuvenating Stem Cells to Restore Muscle Regeneration in Aging 23. Silk Fibroin-Decorin Engineered Biologics to Repair Musculofascial Defects 24. Skeletal Muscle Restoration Following Volumetric Muscle Loss: the Therapeutic Effects of a Biologic Surgical Mesh 25. Principles of Tendon Regeneration 26. Stem Cells and Tendon Regeneration 27. Cell Therapies for Tendon: Treatments and Regenerative Medicine PART 5: NERVE REGENERATION 28. The present and future for peripheral nerve regeneration 29. The Regeneration of Peripheral Nerves Depends on Repair Schwann Cells 30. Adipose-derived Stem Cells (ASCs) for Peripheral Nerve Regeneration 31. Direct Reprogramming Somatic Cells into Functional Neurons: A New Approach to Engineering Neural Tissue in Vitro and in Vivo
