Description
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway. Preface Chapter 1 Role of capsaicin in cancer prevention Chapter 2 Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells Chapter 3 Role of capsaicin in prostate cancer Chapter 4 Capsaicin and the urinary bladder Chapter 5 Inhibition of pancreatitis and carcinogenesis by capsaicin Chapter 6 Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms Chapter 7 The cancer suppressing and promoting actions of capsaicin Chapter 8 Oxidative stress by capsaicin in cancer
