Description
This is a comprehensive and authoritative presentation of total intravenous anesthesia (TIVA) and target controlled infusion (TCI). The editors’ international reputation has enabled them to recruit leading experts from around the world to write single-author chapters in their area of expertise. Total Intravenous Anesthesia and Target Controlled Infusions is the first multi-disciplinary, globally authored volume on the topic. Providing a single source of information on all aspects of TIVA and TCI, from pharmacologic modeling and the pharmacology of intravenous anesthetic drugs to practical considerations in the clinical setting and the requirements of special populations, Total Intravenous Anesthesia and Target Controlled Infusions examines the debate about the risks and advantages of TIVA, analyze outcome studies, and provides guidance on creating a curriculum to teach TIVA and TCI. Anthony R. Absalom, MBChB, FRCA, MD Professor of Anesthesiology, The University Medical Center Groningen, University of Groningen, The Netherlands Dr. Absalom is internationally recognized as a leading expert on anaesthetic pharmacology and total intravenous anesthesia. He currently serves as Editor of the British Journal of Anaesthesia and is a former editorial board member of Trends in Anaesthesia and Critical Care. He is currently president of the Society for Intravenous Anesthesia (UK). In the past he has served as a board member of ISAP (International Society for Intravenous Anaesthesia) and as vice-president of the World Society of Intravenous Anaesthesia. Keira P. Mason, MD is an Associate Professor of Anaesthesia (Radiology) at Harvard Medical School, , Boston Children’s Hospital, Boston, MA. Dr. Mason is a Springer author. We recently published the expanded Second Edition of her critically and globally acclaimed book, Pediatric Sedation Outside of the Operating Room, 2nd ed, Mason, ed., (2015). During 1998-2014, Dr. Mason was Director of Radiology Anesthesia and Sedation at Boston Children’s Hospital, where she developed a sedation and anesthesia program that continues to be nationally and internationally recognized. She is considered a pioneer of innovative and safe sedation protocols which have been adopted worldwide. Dr. Mason is past- Vice President of the World Society of Intravenous Anesthesia (Founding Board Member), and a frequent invited lecturer to national and international conferences, including Society of Interventional Radiology, American Society of Anesthesiologists, Radiological Society of North America, International Dental Congress on Anesthesia, Sedation, and Pain Control, Society of Ambulatory Anesthesia, Asian and Oceanic Society of Regional Anesthesia, Japanese Society for Intravenous Anesthesia, International Association of Pediatric Dentistry, All-African Anaesthesia Congress, Asian Society of Paediatric Anesthesiologists, and many others. She is the Course Director for Pediatric Sedation Outside the Operating Room, a conference she initiated through Harvard Medical School and is an active member of the American Society of Anesthesiologists (ASA) Committees. She has authored many book chapters. As a Principal Investigator of numerous studies, some which required approval of the Food and Drug Administration (FDA), she has numerous publications. Dr. Mason continues to serve on expert panels for the FDA. She is on the Editorial Board of the British Journal of Anaesthesia. CONTENTS PART 1. INTRODUCTION/BACKGROUND 1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia John Sear 2. The Development and Regulation of Commercial Devices for Target – Controlled Drug Infusion John B Glen 3. The Memory Labyrinth: systems, processes and boundaries Robert A. Veselis 4. Consciousness and Anaesthesia Ram Adapa 5. Mechanisms of Intravenous Anaesthetic Action Hugh C. Hemmings Jr and Karl F. Herold PART 2. PRINCIPLES OF PHARMACOLOGICAL MODELING 6. Basic Pharmacology: Kinetics and Dynamics for Dummies Johan Raeder 7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs Johannes Hans Proost 8. Principles of Target Controlled Infusions Steven L. Shafer 9. Performance of Target-Controlled Infusion Systems Matthew TV Chan 10. How to Select a PK/PD Model Kenichi Masui PART 3. PHARMACOLOGY OF THE INTRAVENOUS ANESTHETIC AGENTS 11. Propofol PK-PD Douglas J. Eleveld 12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions Douglas E. Raines 13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children Mohamed Mahmoud 14. Clinical Effects and Applications of Ketamine Mark G. Roback 15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects Claude Meistelman 16. New and Upcoming Drugs: Intravenous Anesthetic Agents John William Sear 17. Drug Interactions in Anesthesia Jaap Vuyk PART 4. PRACTICAL CONDUCT OF SEDATION AND ANESTHESIA 18. Pumps Pitfalls and Practicalities Frank Engbers 19. EEG Monitoring of Depth of Anesthesia Michael Sury 20. Monitoring the analgesic component of anesthesia Isabelle Constant 21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery Keith J Anderson and Gavin NC Kenny 22. Pediatric TIVA/TCI: Case Presentations and Discussion Vivian Man-ying Yuen 23. TCI/TIVA Adult Case Studies Nicholas Sutcliffe PART 5. SPECIAL POPULATIONS AND PROCEDURES 24. Intravenous Anesthesia in Obese Patients Pablo Seplveda and Ignacio Cortnez 25. Pharmacokinetics and Dynamics on the Pediatric Population Brian J. Anderson 26. Clinical Pharmacology of Intravenous Sedation in Children Oliver Bagshaw 27. Sedation of the Critically Ill Child Arno Brouwers, Sanne Vaassen, Gijs D Vos, Jan NM Schieveld, and Piet L Leroy 28. TCI & TIVA for Neurosurgery: Considerations and Techniques Massimo Lamperti and Fazil Ashiq 29. TCI in Special Patients Groups: The Elderly and Obese Frederique S Servin 30. TIVA for Cardiac Surgery Stefan Schraag 31. TIVA/TCI in Veterinary Practice Thierry Beths PART 6. OUTCOME, EDUCATION, SAFETY, AND THE FUTURE 32. Advantages, Disadvantages, and Risks of TIVA/TCI Ken B Johnson 33. Economics of TIVA Jane Montgomery and Mary Stocker 34. Teaching TCI with Human Patient Simulators Wolfgang Heinrichs 35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science and Clinical Impact Ngai Liu 36. Health Care Technology, the Human-Machine Interface, and Patient Safety During Intravenous Anesthesia Craig S. Webster 37. Can IV Sedatives Affect Outcome? Christopher G. Hughes, Christina J. Hayhurst, and Pratik P. Pandharipande 38. The Benefit and Future of Pharmacogenetics Janko Samardzic, Dubravka Svob Strac, and John N. van den Anker 39. Lessons from drug interaction displays Ross Kennedy 40. The Role of Intravenous Agents in Delirium Claudia Spies, Susanne Koch, Alissa Wolf, Rudolf Mrgeli, and Bjrn Weiss 41. Perioperative Cardioprotective Strategies in Noncardiac Surgery Stefan De Hert 42. Opioid Induced Hyperalgesia after Surgery: Clinical Relevance Dr. Philippe Richebe 43. Memory, Awareness and Intravenous Anaesthetics Michael Wang 44. Awareness and Dreaming During TIVA Kate Leslie 45. Apoptosis and Neurocognitive Effects of Intravenous Anesthetics Sulipicio Soriano and Laszlo Vutskits Epilogues
