Description
Derek T. O’Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today’s researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way. An Overview of Adjuvant Use, Robert Edelman. Harmful and Beneficial Activities of Immunological Adjuvants, Duncan E. S. Stewart-Tull. Freund’s Adjuvants, Erik B. Lindblad. Aluminum Compounds as Vaccine Adjuvants, Rajesh K. Gupta and Bradford E. Rost. Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants, Derek T. O’Hagan and Manmohan Singh. Poly(Methyl Methacrylate) Nanoparticles as Vaccine Adjuvants, Jrg Kreuter. Aqueous Formulation of Adjuvant-Active Nonionic Block Copolymers, Charles W. Todd and Mark J. Newman. Liposomes As Immunological Adjuvants and Vaccine Carriers, Gregory Gregoriadis, Brenda McCormack, Mia Obrenovic, Yvonne Perrie, and Roghieh Saffie. Immunopotentiating Reconstituted Influenza Virosomes (IRIVs), Reinhard Glck. Cochleates for Induction of Mucosal and Systemic Immune Responses, Susan Gould-Fogerite and Raphael J. Mannino. Virus-like Particles As Vaccine Adjuvants, Sarah C. Gilbert. The Adjuvant MF59: A 10-Year Perspective, Gary Ott, Ramachandran Radhakrishnan, Jia-Hwa Fang, and Maninder Hora. Preparation of the Syntex Adjuvant Formulation (SAF, SAF-m, and SAF-1), Deborah M. Lidgate. The ISCOM(TM) Technology, Karin Lvgren-Bengtsson and Bror Morein. QS-21 Adjuvant, Charlotte Read Kensil. MPL Immunostimulant: Adjuvant Formulations, J. Terry Ulrich. Cytokines As Vaccine Adjuvants: The Use of Interleukin-2, Martin A. Giedlin. DNA As an Adjuvant, David C. Neujahr and David S. Pisetsky. Transcutaneous Immunization, Gregory M. Glenn, Tanya Scharton-Kersten, and Russell Vassell. Mutant Heat-Labile Enterotoxins As Adjuvants for CTL Induction, Jason A. Neidleman, Gary Ott, and Derek O’Hagan. Index.
