Description
In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience. Part I: Introduction 1. The Past, Present and Future of Chemical Risk Assessment Alice Limonciel Part II: Systemic Organ Toxicity 2. In Vitro Systems for Hepatotoxicity Testing Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif and Patricio Godoy 3. In Vitro Methods for Cardiotoxicity Testing Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou, Jrgen Hescheler and Agapios Sachinidis 4. Renal Cell Culture Paul Jennings, Lydia Aschauer, Anja Wilmes and Gerhard Gstraunthaler 5. Cellular Models for In Vitro Lung Toxicology Oliver H. Wittekindt Part III: Neurotoxicity 6. In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints Anna Bal-Price and Helena T. Hogberg 7. Blood Brain Barrier In Vitro Models and Their Applications in Toxicology Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck, Emmanuel Sevin, Marie-Pierre Dehouck, Romo Cecchelli and Maxime Culot Part IV: Sensory Organ Models 8. Ocular Toxicity Chantra Eskes, Erwin van Vliet, Michael Schffer and Valrie Zuang 9. In Vitro Models for Ototoxic Research Jochen Schacht and Michael G. Leitner Part V: Other Organs and Aspects 10. Dermal Toxicity: Skin Sensitization David Basketter and Silvia Casati 11. Immunotoxicity Thomas Hartung 12. Reproductive Toxicity Giovanna Lazzari and Cesare Galli 13. Evaluating Endocrine Disruption In Vitro Patrick J. Devine 14. Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity Federica Madia, Pascal Phrakonkham, and Raffaella Corvi Part VI: The Use of Stem Cells 15. Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening Caroline Rauch, Paul Jennings, and Anja Wilmes 16. Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing Ellen Fritsche Part VII: Techniques and Markers 17. High Content Imaging Approaches for In Vitro Toxicology Marianne Uteng, Davide Germano, Kamal Kumar Balavenkatraman, Francois Pognan, and Armin Wolf 18. Application of Omics Technologies to In Vitro Toxicology Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T. Hogberg, and Erwin van Vliet 19. Stress Response Pathways Martin O. Leonard, Alice Limonciel, and Paul Jennings 20. Translational Biomarkers, In Vitro and In Vivo Anja Wilmes, Alice Limonciel, Martin O. Leonard, and Paul Jennings Part VIII: Challenges and Considerations 21. Nanotoxicology Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti and Franois Rossi 22. Consideration of Metabolism in In Vitro Cellular Systems Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola, and Miia Turpeinen 23. In Vitro Approaches to Predictive Biokinetics Bas J. Blaauboer 24. Extrapolating In Vitro Results to Predict Human Toxicity Nadia Quignot, Jrmy Hamon, and Frederic Y. Bois 25. Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use Sandra Coecke, Gerard Bowe, Anne Milcamps, Camilla Bernasconi, Ann-Charlotte Bostroem, Gilles Bories, Salvador Fortaner, Jean-Michel Gineste, Varvara Gouliarmou, Ingrid Langezaal, Roman Liska, Emilio Mendoza, Siegfried Morath, Vittorio Reina, Iwona Wilk-Zasadna and Maurice Whelan.
