Description
This volume presents key topics of current interest with regard to several pathophysiological conditions including (a) the basic and clinical aspects of bradykinin receptor antagonists, (b) the kallikrein-kinin pathways in hypertension and diabetes, (c) tissue kallikrein-kinin therapy for hypertension and organ damage, (d) the renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension, (e) the kallikrein-kinin system in diabetes retinopathy, and (f) genetic manipulation and genetic variation of the kallikrein-kinin system and their impacts on cardiovascular and renal disease. Written by internationally reputed scientists, the book provides an essential overview of the latest developments in the field of kinin research, making it a valuable asset for endocrinologists, nephrologists, cardiologists, pharmacologists, physiologists, ophthalmologists and rheumatologists. Furthermore, it is also intended for postgraduate students in the fields of medicine, pharmacy, physiology and pharmacology, and those working at research organizations. 1 Basic and clinical aspects of bradykinin receptor antagonists J.N. Sharma 2 The kallikrein-kinin pathways in hypertension and diabetes J.N. Sharma and P. Narayanan 3 Tissue Kallikrein-kinin therapy in hypertension and organ damage J. Chao, G. Bledsoe, and L. Chao 4 Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension M. Katori and M. Majima 5 The Kallikrein-kinin system in diabetic retinopathy M. Bhat, M. Pouliot, R. Couture and E. Vaucher 6 Genetic manipulation and genetic variation of the Kallikrein Kinin System; impact on cardiovascular and renal diseases Jean-Pierre Girolami, Nelly Blaes, Nadine Bouby, Franois Alhenc-Gelas
